The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers
نویسندگان
چکیده
منابع مشابه
The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation.
The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a global structural similarity was found between Bap, a biofilm-associated protein of Staphylococcus aureus, and Esp. Analysis of the relationship between the presence of the Esp-enc...
متن کاملMolecular Detection of Enterococcal Surface Protein (esp) Gene in Enterococcus faecalis Isolated from Dental Calculus of Patients in Sari, Iran
Background: Enterococci are important gram-positive bacteria causing dental calculus in human beings; however, the role of these bacteria in oral cavity is unclear. The aim of this study was to investigate the presence of Enterococcal Surface Protein (esp) gene in Enterococcus faecalis isolated from dental calculus in the city of Sari, Iran. Materials and Methods: In the present study, 207 den...
متن کاملRole of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection.
Enterococcus faecalis bacteria isolated from patients with bacteremia, endocarditis, and urinary tract infections more frequently express the surface protein Esp than do fecal isolates. To assess the role of Esp in colonization and persistence of E. faecalis in an animal model of ascending urinary tract infection, we compared an Esp(+) strain of E. faecalis to its isogenic Esp-deficient mutant....
متن کاملInfection-derived Enterococcus faecalis strains are enriched in esp, a gene encoding a novel surface protein.
We report the identification of a new cell wall-associated protein of Enterococcus faecalis. Studies on the distribution of the gene encoding this novel surface protein, Esp, reveal a significant (P < 0.001) enrichment in infection-derived E. faecalis isolates. Interestingly, the esp gene was not identified in any of 34 clinical E. faecium isolates or in 4 other less pathogenic enterococcal spe...
متن کاملEnterococcal surface protein Esp is important for biofilm formation of Enterococcus faecium E1162.
Enterococci have emerged as important nosocomial pathogens with resistance to multiple antibiotics. Adhesion to abiotic materials and biofilm formation on medical devices are considered important virulence properties. A single clonal lineage of Enterococcus faecium, complex 17 (CC17), appears to be a successful nosocomial pathogen, and most CC17 isolates harbor the enterococcal surface protein ...
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ژورنال
عنوان ژورنال: npj Biofilms and Microbiomes
سال: 2020
ISSN: 2055-5008
DOI: 10.1038/s41522-020-0125-2